Enantiopure D-amino Acid Analogs Made Using Enzymes

As peptide therapeutics experience explosive growth, the need to address the pharmacokinetic liabilities of canonical L-amino acids grows. D-amino acids are less susceptible to enzymatic degradation and, when placed appropriately in a peptide or protein sequence, can confer additional selectivity and potency.

Combining the D-enantiomeric space with the versatile Aralez Bio functional group and positional space leads to an expansive chemical diversity with endless possibilities.

Incorporate D-amino acids into your workflow to:

• screen expanded chemical space
• improve protease stability
• improve binding affinity & specificity
• design molecules from mirror image display
• optimize peptide-target interactions
• perform racemic crystallography
• identify key interactions with D-amino acid scanning
• alter secondary structure
• drive self-assembly

Download the Latest Compound Information on D-amino Analogs